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1

The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer’s disease

Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra K., Xue, Wei-Feng, McGeehan, John E., Atack, John R., Serpell, Louise

Journal:

Journal of Molecular Biology

Year:

2019

Language:

english

File:

PDF, 1.12 MB

english, 2019

2

Reduction of tank main gun noise with a muffler

Atack, Rodney M., Bales, Joel D., Wrobel, John G., Lewis, Nelson D.

Journal:

The Journal of the Acoustical Society of America

Year:

1985

Language:

english

File:

PDF, 552 KB

english, 1985

3

Inositol monophosphatase inhibitors—Lithium mimetics?

Journal:

Medicinal Research Reviews

Year:

1997

Language:

english

File:

PDF, 329 KB

english, 1997

4

REPORTS UPON LUNATIC ASYLUMS FOR 1886.

Atack, John, Lauffart, Brenda, Mantle, David, Perry, Elaine

Journal:

Year:

1887

Language:

english

File:

PDF, 452 KB

english, 1887

5

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies

Atack, John M., Tan, Aimee, Bakaletz, Lauren O., Jennings, Michael P., Seib, Kate L.

Journal:

Trends in Microbiology

Year:

2018

Language:

english

File:

PDF, 1.63 MB

english, 2018

6

Reduction of tank main gun noise with a muffler

Atack, Rodney M., Bales, Joel D., Wrobel, John G., Lewis, Nelson D.

Journal:

The Journal of the Acoustical Society of America

Year:

1985

File:

PDF, 552 KB

1985

7

Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens

Seib, Kate L., Srikhanta, Yogitha N., Atack, John M., Jennings, Michael P.

Journal:

Annual Review of Microbiology

Year:

2020

File:

PDF, 688 KB

2020

8

Cerebrospinal fluid cholinesterases in aging and in dementia of the alzheimer type

Dr. John R. Atack, Conrad May, Jeffrey A. Kaye, Arthur D. Kay, Stanley I. Rapoport

Journal:

Annals of Neurology

Year:

1988

Language:

english

File:

PDF, 767 KB

english, 1988

9

Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease

Dr. Jeffrey A. Kaye, Conrad May, John R. Atack, Eileen Daly, Daniel L. Sweeney, M. Flint Beal, Seymour Kaufman, Sheldon Milstien, Robert P. Friedland, Stanley I. Rapoport

Journal:

Annals of Neurology

Year:

1988

Language:

english

File:

PDF, 459 KB

english, 1988

10

Physostigmine treatment of progressive supranuclear palsy

Irene Litvan, Claudia Gomez Med, John R. Atack, Marjorie Gillespie, Anne M. Kask, M. Maral Mouradian, Dr Thomas N. Chase

Journal:

Annals of Neurology

Year:

1989

Language:

english

File:

PDF, 457 KB

english, 1989

11

Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands

Andrew Pike, Susan M. Cook, Alan P. Watt, Paul Scott-Stevens, Thomas W. Rosahl, Ruth M. McKernan, Luanda J. Pym, Alec Guiblin, Christopher Moyes, Bindi Sohal, John R. Atack

Journal:

Biopharmaceutics & Drug Disposition

Year:

2007

Language:

english

File:

PDF, 157 KB

english, 2007

12

3,4-Dihydronaphthalen-1(2H)-ones: Novel Ligands for the Benzodiazepine Site of α5-Containing GABAA Receptors.

Helen J. Szekeres, John R. Atack, Mark S. Chambers, Susan M. Cook, Alison J. Macaulay, Gopalan V. Pillai, Angus M. MacLeod

Journal:

Year:

2004

Language:

english

File:

PDF, 93 KB

english, 2004

13

Physovenines: Efficient Synthesis of (−)- and (+)-Physovenine and Synthesis of Carbarnate Analogues of (−)-Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines

Qian-sheng Yu, Chi Liu, Margareth Brzostowska, Linda Chrisey, Arnold Brossi, Nigel H. Greig, John R. Atack, Timothy T. Soncrant, Stanley I. Rapoport, Hans-Eckart Radunz

Journal:

Helvetica Chimica Acta

Year:

1991

Language:

english

File:

PDF, 382 KB

english, 1991

14

Pyrazolopyridinones as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, Richard Lewis, Michael G.N. Russell, Alison Smith, Keith Wafford, Ruth M. McKernan, Leslie J. Street, José L. Castro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

15

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunction

Philip Jones, John R. Atack, Matthew P. Braun, Brian P. Cato, Mark S. Chambers, Desmond O’Connor, Susan M. Cook, Sarah C. Hobbs, Robert Maxey, Helen J. Szekeres, Nicola Szeto, Keith A. Wafford, Angus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

16

Imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, José L. Castro, Simon C. Goodacre, David J. Hallett, Richard T. Lewis, George R. Marshall, Andrew Pike, Alison J. Smith, Leslie J. Street, David F.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 151 KB

english, 2006

17

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Simon C. Goodacre, David J. Hallett, Robert W. Carling, José L. Castro, David S. Reynolds, Andrew Pike, Keith A. Wafford, Robert Newman, John R. Atack, Leslie J. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

18

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

Robert W. Carling, Michael G.N. Russell, Kevin W. Moore, Andrew Mitchinson, Alexander Guiblin, Alison Smith, Keith A. Wafford, George Marshall, John R. Atack, Leslie J. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

19

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists

Emily M. Stocking, Leah Aluisio, John R. Atack, Pascal Bonaventure, Nicholas I. Carruthers, Christine Dugovic, Anita Everson, Ian Fraser, Xiaohui Jiang, Perry Leung, Brian Lord, Kiev S. Ly, Kirsten L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 574 KB

english, 2010

20

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development

Michael A. Letavic, Leah Aluisio, John R. Atack, Pascal Bonaventure, Nicholas I. Carruthers, Christine Dugovic, Anita Everson, Mark A. Feinstein, Ian C. Fraser, Kenway Hoey, Xiaohui Jiang, John M. Kei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

21

A comparative assessment of γ-secretase activity in transgenic and non-transgenic rodent brain

Julian L. Goggi, Huw D. Lewis, Joanie Mok, Tim Harrison, Mark S. Shearman, John R. Atack, Jonathan D. Best

Journal:

Journal of Neuroscience Methods

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

22

4-hydroxyphenoxymethylene bisphosphonic acid derivatives: potent, non-hydrolysable inhibitors of MYO-inositol monophosphatase

Stephen R. Fletcher, Raymond Baker, Tamara Ladduwahetty, Andrew Sharpe, Martin Teall, John R. Atack

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 290 KB

english, 1993

23

Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N-Methyl-d-Aspartate Receptor Subtypes

Sarah Grimwood, Béatrice Le Bourdellès, John R. Atack, Cheryl Barton, Wendy Cockett, Susan M. Cook, Elizabeth Gilbert, Peter H. Hutson, Ruth M. McKernan, Jan Myers, C. Ian Ragan, Peter B. Wingrove, Pa

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

24

Detection of gender differences in rat lens proteins using 2-D-DIGE

Paul C. Guest, Heather A. Skynner, Kamran Salim, F. David Tattersall, Michael R. Knowles, John R. Atack

Journal:

Year:

2006

Language:

english

File:

PDF, 957 KB

english, 2006

25

Evidence for a membrane lipid defect in Alzheimer disease

Lionel Ginsberg, John R. Atack, Stanley I. Rapoport, Norman L. Gershfeld

Journal:

Molecular and Chemical Neuropathology (Neurochemical Pathology)

Year:

1993

Language:

english

File:

PDF, 787 KB

english, 1993

26

Development of Selective Ligands for Benzodiazepine Receptor Subtypes by Manipulating the Substituents at Positions 3- and 7- of Optically Active BzR Ligands

Xiaoyan Li, Jianming Yu, John R. Atack, James M. Cook

Journal:

Medicinal Chemistry Research

Year:

2004

File:

PDF, 837 KB

2004

27

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2receptor

James R. Shoblock, Natalie Welty, Diane Nepomuceno, Brian Lord, Leah Aluisio, Ian Fraser, S. Timothy Motley, Steve W. Sutton, Kirsten Morton, Ruggero Galici, John R. Atack, Lisa Dvorak, Devin M. Swans

Journal:

Psychopharmacology

Year:

2010

Language:

english

File:

PDF, 311 KB

english, 2010

28

Contribution of GABAAreceptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys

Bradford D. Fischer, John R. Atack, Donna M. Platt, David S. Reynolds, Gerard R. Dawson, James K. Rowlett

Journal:

Psychopharmacology

Year:

2011

Language:

english

File:

PDF, 207 KB

english, 2011

29

Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands

James Crawforth, John R. Atack, Susan M. Cook, Karl R. Gibson, Alan Nadin, Andrew P. Owens, Andrew Pike, Michael Rowley, Alison J. Smith, Bindi Sohal, Francine Sternfeld, Keith Wafford, Leslie J. Stre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 196 KB

english, 2004

30

3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of α5-containing GABAA receptors

Helen J. Szekeres, John R. Atack, Mark S. Chambers, Susan M. Cook, Alison J. Macaulay, Gopalan V. Pillai, Angus M. MacLeod

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

31

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor

Andrew Mitchinson, John R. Atack, Peter Blurton, Robert W. Carling, José L. Castro, Karen S. Curley, Michael G. N. Russell, George Marshall, Ruth M. McKernan, Kevin W. Moore, Robert Narquizian, Alison

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

32

Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Andrew S.R. Jennings, Richard T. Lewis, Michael G.N. Russell, David J. Hallett, Leslie J. Street, José L. Castro, John R. Atack, Susan M. Cook, Rachael Lincoln, Joanna Stanley, Alison J. Smith, David

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 134 KB

english, 2006

33

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

Elaine K. Perry, John R. Atack, Robert H. Perry, John A. Hardy, Peter R. Dodd, James A. Edwardson, Garry Blessed, Bernard E. Tomlinson, Andrew F. Fairbairn

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 943 KB

english, 1984

34

Neocortical Cholinergic Enzyme and Receptor Activities in the Human Fetal Brain

Elaine K. Perry, Carthage J. Smith, John R. Atack, John M. Candy, Mary Johnson, Robert H. Perry

Journal:

Journal of Neurochemistry

Year:

1986

Language:

english

File:

PDF, 918 KB

english, 1986

35

Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in the Aged Human Central Nervous System

John R. Atack, Elaine K. Perry, James R. Bonham, John M. Candy, Robert H. Perry

Journal:

Journal of Neurochemistry

Year:

1986

Language:

english

File:

PDF, 1.47 MB

english, 1986

36

Molecular Forms of Butyrylcholinesterase in the Human Neocortex During Development and Degeneration of the Cortical Cholinergic System

John R. Atack, Elaine K. Perry, James R. Bonham, John M. Candy, Robert H. Perry

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 681 KB

english, 1987

37

Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in Human Plasma and Cerebrospinal Fluid

John R. Atack, Elaine K. Perry, James R. Bonham, Robert H. Perry

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 674 KB

english, 1987

38

Measurement of Lithium-Induced Changes in Mouse Inositol(1)Phosphate Levels In Vivo

John R. Atack, Susan M. Cook, Alan P. Watt, C. Ian Ragan

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 997 KB

english, 1992

39

In Vitro and In Vivo Inhibition of Inositol Monophosphatase by the Bisphosphonate L-690,330

John R. Atack, Susan M. Cook, Alan P. Watt, Stephen R. Fletcher, C. Ian Ragan

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 710 KB

english, 1993

40

The plasma–occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, α5IA, is similar in rats and primates

John R Atack, Wai-si Eng, Ray E Gibson, Christine Ryan, Barbara Francis, Bindi Sohal, Gerard R Dawson, Richard J Hargreaves, H Donald Burns

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 281 KB

english, 2009

41

GABAA Receptor Subtype-Selective Efficacy: TPA023, an α2/α3 Selective Non-sedating Anxiolytic and α5IA, an α5 Selective Cognition Enhancer

Journal:

CNS Neuroscience & Therapeutics

Year:

2008

Language:

english

File:

PDF, 556 KB

english, 2008

42

The 5HT1B receptor agonist, CP-93129, inhibits [3H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated rat

Anita Chadha, Cyrille Sur, John Atack, Susan Duty

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

43

Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors

John R Atack, Peter H Hutson, Neil Collinson, George Marshall, Graham Bentley, Christopher Moyes, Susan M Cook, Ian Collins, Keith Wafford, Ruth M McKernan, Gerard R Dawson

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

44

Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513

Luanda J Pym, Susan M Cook, Thomas Rosahl, Ruth M McKernan, John R Atack

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 204 KB

english, 2005

45

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

Collins, Ian, Moyes, Christopher, Davey, William B., Rowley, Michael, Bromidge, Frances A., Quirk, Kathleen, Atack, John R., McKernan, Ruth M., Thompson, Sally-Ann, Wafford, Keith

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 169 KB

english, 2002

46

Substrate recognition and catalysis by flap endonucleases and related enzymes

Tomlinson, Christopher G., Atack, John M., Chapados, Brian, Tainer, John A., Grasby, Jane A.

Journal:

Biochemical Society Transactions

Year:

2010

Language:

english

File:

PDF, 420 KB

english, 2010

47

Regional analysis of rat brain proteins during senescence

James W. Cosgrove, John R. Atack, Stanley I. Rapoport

Journal:

Experimental Gerontology

Year:

1987

Language:

english

File:

PDF, 1.26 MB

english, 1987

48

pp60c-src Kinase expression in brain of adult rats in relation to age

Martha F. Matocha, Sean W. Fitzpatrick, John R. Atack, Stanley I. Rapoport

Journal:

Experimental Gerontology

Year:

1990

Language:

english

File:

PDF, 805 KB

english, 1990

49

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor

Devin M. Swanson, Victoria D. Wong, Jill A. Jablonowski, Chandra Shah, Dale A. Rudolph, Curt A. Dvorak, Mark Seierstad, Lisa K. Dvorak, Kirsten Morton, Diane Nepomuceno, John R. Atack, Pascal Bonavent

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.73 MB

english, 2011

50

The complexity of the GABAA receptor shapes unique pharmacological profiles

Charlotte D’Hulst, John R. Atack, R. Frank Kooy

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009